Gals Can't Be Kind to Otaku!?

The story centers on Hideki Nishimura, a young man who confessed to a person he thought was a girl online, only for that person to turn out to be a boy. He keeps this "black history" secret and swears to never to trust a "girl" online again. However, one day a girl online confesses to him, and it turns out she's actually a beautiful girl named Ako Tamaki. Ako cannot tell the difference between the online world and reality, and she is a loner who has trouble communicating. Hideki and his friends from his guild decide to work together to "correct" her.

Fashionable and upbeat high schooler Aya falls head over heels for an employee at a local CD shop. He's got an air of mystery about him, great style, and an impeccable music taste. Little does she know—this supposedly male employee is actually her female classmate Mitsuki! Mitsuki generally keeps to herself, but since her seat is right next to Aya's, she can't help but be extremely aware of the other's crush. Revealing the truth is out of the question for Mitsuki—but perhaps getting closer to Aya wouldn't be so bad...

Keita Amano is a fan of one thing: gaming! Whether he’s on his phone or console, he just loves playing video games. And when the beautiful president of the game club, Karen Tendou, invites him to join, it seems like an EZ choice. Except, he declines! KO’d by the shock, Karen suddenly makes getting close to Amano her main quest. But she’s not the only one interested in him!

Sasahara Kanji is a college freshman who decides to join a student society to share his hidden thoughts on manga, anime and gaming. When he first visited Genshiken, short for "Gendai Shikaku Bunka Kenkyuu Kai" (Society for the Study of Modern Visual Culture), his groundless pride was destroyed by the plotting of Madarame, a sophomore student in Genshiken, but he still couldn't admit that he is an otaku. However, as he participates in society activities such as visiting dojin (private publishing) shops and anime festivals, and hangs out with other society members Kosaka (a hardcore otaku despite his extreme eccentricities and good looks), Kosaka's girlfriend Kasuga Saki (who isn't really an otaku), Ohno (a cosplayer) and the others, he opens his mind and resolves that he will make his way into the otaku world. With their help, Sasahara slowly adjusts to otaku life in Genshiken.