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In the distant future, human beings have been forced to leave earth and migrate to another galaxy. An advanced team of spacecraft arrives at a planet that is to be terraformed. Each member of the team is output by a biological 3D printer.

In 2099, Earth has shifted off its axis and begins to rotate at an angle of 90% to the 20th-century equator. Three years of natural disasters follows, and when things settle down, Earth's ten billion population has died and only two million moon colonists remain. Some return to begin the repopulation of the world in seven new cities and the remaining colonists of the moon fear that their former neighbors might pose a threat and construct a ring of defensive satellites to trap them on the newly repopulated homeworld.

It is 2046 when a mysterious alien force begins their annihilation of the human race. Leaving behind the one person she loves, Mikako joins the interstellar battle as a pilot. And so - while Mikako risks her life to save mankind - Noboru waits. At first days, then months, then years for each new message that will let him know whether Mikako is still alive. And, while she barely grows older in the timelessness of space, Noboru ages. The two lovers, worlds apart, desperately strive to remain connected as the gap between them widens at a frightening pace.

New Cosmic Century 038, humanity is suddenly attacked by an unknown alien civilization known as the Orbital Ring System. Soon, the entire Earth Civilization Sphere has been cut off from the space colonies, and is under the control of the ORS. Only Hayabusha Jetter, along with his band of misfit space pirates and smugglers, can break through ORS lines.